skip to main content


Search for: All records

Creators/Authors contains: "Hoffmann, H."

Note: When clicking on a Digital Object Identifier (DOI) number, you will be taken to an external site maintained by the publisher. Some full text articles may not yet be available without a charge during the embargo (administrative interval).
What is a DOI Number?

Some links on this page may take you to non-federal websites. Their policies may differ from this site.

  1. Freeman, S. ; Lederer-Woods, C. ; Manna, A. ; Mengoni, A. (Ed.)
    The thermodynamical conditions and the neutron density produced in a laser-induced implosion of a deuterium-tritium (DT) filled capsule at the National Ignition Facility (NIF) are the closest laboratory analog of stellar conditions. We plan to investigate neutron-induced reactions on 40 Ar, namely the 40 Ar( n , 2 n ) 39 Ar( t 1/2 =268 y), the 40 Ar( n , γ) 41 Ar(110 min) and the potential rapid two-neutron capture reaction 40 Ar(2 n , γ) 42 Ar(33 y) in an Ar-loaded DT capsule. The chemical inertness of noble gas Ar enables reliable collection of the reaction products. 
    more » « less
  2. Molecular virology tools are critical for basic studies of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and for developing new therapeutics. Experimental systems that do not rely on viruses capable of spread are needed for potential use in lower-containment settings. In this work, we use a yeast-based reverse genetics system to develop spike-deleted SARS-CoV-2 self-replicating RNAs. These noninfectious self-replicating RNAs, or replicons, can be trans-complemented with viral glycoproteins to generate replicon delivery particles for single-cycle delivery into a range of cell types. This SARS-CoV-2 replicon system represents a convenient and versatile platform for antiviral drug screening, neutralization assays, host factor validation, and viral variant characterization. 
    more » « less
  3. —We describe how classical supercomputing can aid unreliable quantum processors of intermediate size to solve large problem instances reliably. We advocate using a hybrid quantum-classical architecture where larger quantum circuits are broken into smaller sub-circuits that are evaluated separately, either using a quantum processor or a quantum simulator running on a classical supercomputer. Circuit compilation techniques that determine which qubits are simulated classically will greatly impact the system performance as well as provide a tradeoff between circuit reliability and runtime. 
    more » « less